An analysis evaluating RAD51 test and its association with HRD and clinical outcome in primary TNBC from GeparSixto trial has been published in Annals of Oncology.
This study compared an immunohistology-based RAD51 test with genetic/genomic tests to identify patients with homologous recombination deficiency (HRD) primary triple-negative breast cancer (TNBC) and evaluates its accuracy to select patients sensitive to platinum-based neoadjuvant chemotherapy (NACT).
Conclusion: The RAD51 test identifies tumors with functional HRD and is highly concordant with tBRCA mutation and genomic HRD. RAD51 independently predicts clinical benefit from adding carboplatin to NACT in TNBC. Our results support further development to incorporate RAD51 testing in clinical decision-making.
Llop-Guevara A, Loibl S, Villacampa G, et al. Association of RAD51 with homologous recombination deficiency (HRD) and clinical outcomes in untreated triple-negative breast cancer (TNBC): analysis of the GeparSixto randomized clinical trial. Ann Oncol. 2021;32:1590-1596.